Pharmaco-metabonomic phenotyping and personalized drug treatment
نویسندگان
چکیده
منابع مشابه
Pharmaco-EEG, Pharmaco-Sleep and EEG-Based Personalized Medicine.
the haemodynamic or metabolic measures assessed by imaging techniques such as fMRI or FDG-PET. EEG is also unique in its direct applicability in both humans and animals. In totality, pharmaco-EEG encompasses a number of non-invasive methods that can be used routinely to assess the effects of pharmacological compounds on the CNS. Pharmaco-EEG can thus help further understanding of brain dynamics...
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MicroRNAs (miRNAs) are short regulatory RNAs that down-regulate gene expression. They are essential for cell homeostasis and active in many disease states. A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the field of 'miRNA pharmacogenomics' through 'Pharmaco-miRs'. miRNAs play a significant role in pharmacogenomics by down-regulating genes...
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The pharmaceutical industry has been suffering from low clinical success rates of new drugs for some time with particularly high attrition in early clinical development, especially for drugs aimed at central targets. Both pharmaco-electroencephalography (EEG) and pharmaco-sleep, along with other biomarker techniques, have significant potential to assist with this problem by enabling early decis...
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Differences in metabolic patterns as result of genotype variations or environmental factors have been known to alter drug efficacies and adverse reactions of drug molecules and attempts are being made to individualize drug dosages. Important amongst these are differences in drug effects due to pre-systemic metabolism arising out of different routes of administration particularly for those drugs...
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ژورنال
عنوان ژورنال: Nature
سال: 2006
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature04648